Back to Search Start Over

Assessment of Severity of Long QT Syndrome Phenotype and Risk of Fetal Death

Authors :
Lisa Albertini
Jordan Ezekian
Melanie Care
Candice Silversides
Mathew Sermer
Michael H. Gollob
Danna Spears
Source :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 23 (2023)
Publication Year :
2023
Publisher :
Wiley, 2023.

Abstract

Background It has been postulated that long QT syndrome (LQTS) can cause fetal loss through putative adverse effects of the channelopathy on placenta and myometrial function. The authors aimed to describe the fetal death rate in a population of pregnant women with long QT syndrome and investigate whether women with more severe phenotype had worse fetal outcomes. Methods and Results The authors retrospectively evaluated fetal outcomes of 64 pregnancies from 23 women with long QT syndrome followed during pregnancy in a tertiary pregnancy and heart disease program. Thirteen of 64 pregnancies (20%) resulted in a fetal loss, 12 miscarriages (19%), and 1 stillbirth (1.6%). Baseline maternal characteristics, including age and use of β‐blockers, did not differ between women who experienced a fetal death or not. Maternal corrected QT interval (QTc) was significantly longer in pregnancies that resulted in fetal death compared with live births (median, 518 ms [interquartile range (IQR), 482‐519 ms] versus 479 ms [IQR, 454–496 ms], P500 ms was significantly lower compared with women with QTc 500 ms is lower, suggesting that patients with more marked phenotype may experience worse fetal outcomes.

Details

Language :
English
ISSN :
20479980
Volume :
12
Issue :
23
Database :
Directory of Open Access Journals
Journal :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.2265ccf302714d93af98bc62a6d52bf7
Document Type :
article
Full Text :
https://doi.org/10.1161/JAHA.122.029407