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Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats
- Source :
- BMC Veterinary Research, Vol 18, Iss 1, Pp 1-10 (2022)
- Publication Year :
- 2022
- Publisher :
- BMC, 2022.
-
Abstract
- Abstract Aim This study aimed to investigate the efficiency of topically applied pycnogenol (PYC) in healing the standardized alkaline corneal ulcer in diabetic and normal rats. Materials and methods The corneal alkali-burn injury (CA-I) model was unilaterally developed in Wistar rats by filter paper saturated with 0.01 M of NaOH and touching the eyes for 45 s. Rats were divided into four groups: Normal control (NC), normal PYC (NPYC), diabetic control (DC), and diabetic PYC (DPYC). Both NPYC and DPYC groups were daily treated with PY eye drops three times, whereas NC and DC ones were treated with ordinary saline for six successive days. Results The wound healing of corneal epithelial was improved in the NPYC group compared to the NC group. Meanwhile, it was significantly improved (P
- Subjects :
- Pycnogenol
Cornea
Epithelium
Diabetes
Wound healing
Veterinary medicine
SF600-1100
Subjects
Details
- Language :
- English
- ISSN :
- 17466148
- Volume :
- 18
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- BMC Veterinary Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.21ca9c8b0f4e4723ab2c4007a3a38791
- Document Type :
- article
- Full Text :
- https://doi.org/10.1186/s12917-022-03307-3