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Prognostic Implications of Postoperative Infectious Complications in Non-Small Cell Lung Cancer
- Source :
- Korean Journal of Thoracic and Cardiovascular Surgery, Vol 51, Iss 1, Pp 41-52 (2018)
- Publication Year :
- 2018
- Publisher :
- Korean Society for Thoracic and Cardiovascular Surgery, 2018.
-
Abstract
- Background: Few studies have evaluated the long-term impact of postoperative infectious complications in patients with non-small cell lung cancer (NSCLC). We aimed to determine the impact of infectious complications on long-term outcomes after surgical resection for NSCLC. Methods: We performed a retrospective study of 1,380 eligible patients who underwent pulmonary resection for NSCLC from 2003 to 2012. Complications were divided into infectious complications and non-infectious complications. Kaplan-Meier survival analysis was used to compare unadjusted 5-year cancer-specific survival (CSS) rates and recurrence-free survival (RFS) rates. Cox regression was used to determine the impact of infectious complications on 5-year CSS and RFS. Results: The rate of total complications and infectious complications was 24.3% and 4.3%, respectively. In the node-negative subgroup, the 5-year CSS and RFS rates were 75.9% and 57.1% in patients who had infectious complications, compared to 87.9% and 78.4% in patients who had no complications. Infectious complications were a negative prognostic factor for 5-year RFS (hazard ratio, 1.92; 95% confidence interval, 1.00–3.69; p=0.049). In the node-positive subgroup, the 5-year CSS rate and RFS were 44.6% and 48.4% in patients who had infectious complications, compared to 70.5% and 48.4% for patients who had no complications. Conclusion: Postoperative infectious complications had a negative impact on CSS and RFS in node-negative NSCLC. Our findings may help improve risk assessment for tumor recurrence after pulmonary resection for node-negative NSCLC.
- Subjects :
- Non-small-cell lung carcinoma
Complication
Prognosis
Surgery
RD1-811
Subjects
Details
- Language :
- English, Korean
- ISSN :
- 2233601X and 20936516
- Volume :
- 51
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Korean Journal of Thoracic and Cardiovascular Surgery
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.21ba42be60304714aca43ebae00b1ec3
- Document Type :
- article
- Full Text :
- https://doi.org/10.5090/kjtcs.2018.51.1.41