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Antimicrobial Susceptibility Patterns and Resistance Trends of Staphylococcus aureus and Coagulase-Negative Staphylococci Strains Isolated from Ocular Infections

Authors :
Francesco Petrillo
Danilo Pignataro
Federica Maria Di Lella
Michele Reibaldi
Matteo Fallico
Niccolò Castellino
Guglielmo Parisi
Maria Consiglia Trotta
Michele D’Amico
Biagio Santella
Veronica Folliero
Maria Teresa Della Rocca
Michele Rinaldi
Gianluigi Franci
Teresio Avitabile
Marilena Galdiero
Giovanni Boccia
Source :
Antibiotics, Vol 10, Iss 5, p 527 (2021)
Publication Year :
2021
Publisher :
MDPI AG, 2021.

Abstract

Ocular bacterial infections represent a serious problem that affecting people of all age and genders. These infections can lead to visual impairment and blindness if not properly treated. The current study evaluates the antimicrobial resistance profiles and the resistance trend of both Staphylococcus aureus (S. aureus) and coagulase-negative staphylococci (CoNS), the main pathogens involved in eye infections. A total of 322 isolates of S. aureus and CoNS, were collected from patients with bacterial conjunctivitis and keratitis at the “Luigi Vanvitelli” University Hospital of Campania in Naples, Italy, between 2017 and 2020. The isolated bacteria showed a high percentage of resistance to methicillin and other antibiotics commonly used for the treatment of ocular infections. Trends in antibiotic resistance were not encouraging, recording—especially among CoNS strains—an increase of more than 20% in resistance to methicillin and aminoglycosides during the study period. Instead, the resistance rates to tetracycline had a significant decrease in CoNS isolates while no changes in their susceptibility to fluoroquinolones and macrolides were observed. However, all isolates showed no resistance to trimethoprim/sulfamethoxazole and chloramphenicol. In this scenario, preventive identification of the infection causative agents and the evaluation of the antimicrobial susceptibility patterns are essential to set up an ocular infection effective drug treatment and also prevent antibiotic resistance.

Details

Language :
English
ISSN :
20796382
Volume :
10
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Antibiotics
Publication Type :
Academic Journal
Accession number :
edsdoj.2173198934628a252cba747bb39ef
Document Type :
article
Full Text :
https://doi.org/10.3390/antibiotics10050527