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Saliva and Serum Immune Responses in Apical Periodontitis
- Source :
- Journal of Clinical Medicine, Vol 8, Iss 6, p 889 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Apical periodontitis is an inflammatory reaction at the apex of an infected tooth. Its microbiota resembles that of marginal periodontitis and may induce local and systemic antibodies binding to bacteria- and host-derived epitopes. Our aim was to investigate the features of the adaptive immune response in apical periodontitis. The present Parogene cohort (n = 453) comprises patients with cardiac symptoms. Clinical and radiographic oral examination was performed to diagnose apical and marginal periodontitis. A three-category endodontic lesion score was designed. Antibodies binding to the bacteria- and host-derived epitopes were determined from saliva and serum, and bacterial compositions were examined from saliva and subgingival samples. The significant ORs (95% CI) for the highest endodontic scores were observed for saliva IgA and IgG to bacterial antigens (2.90 (1.01−8.33) and 4.91 (2.48−9.71)/log10 unit), saliva cross-reacting IgG (2.10 (1.48−2.97)), serum IgG to bacterial antigens (4.66 (1.22−10.1)), and Gram-negative subgingival species (1.98 (1.16−3.37)). In a subgroup without marginal periodontitis, only saliva IgG against bacterial antigens associated with untreated apical periodontitis (4.77 (1.05−21.7)). Apical periodontitis associates with versatile adaptive immune responses against both bacterial- and host-derived epitopes independently of marginal periodontitis. Saliva immunoglobulins could be useful biomarkers of oral infections including apical periodontitis—a putative risk factor for systemic diseases.
- Subjects :
- apical periodontitis
adaptive immunity
saliva
serum
antibody
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 8
- Issue :
- 6
- Database :
- Directory of Open Access Journals
- Journal :
- Journal of Clinical Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.21638f9ae57c4cc5a789be7413871161
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/jcm8060889