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Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish

Authors :
Julia Y. Kam
Elinor Hortle
Elizabeth Krogman
Sherridan E. Warner
Kathryn Wright
Kaiming Luo
Tina Cheng
Pradeep Manuneedhi Cholan
Kazu Kikuchi
James A. Triccas
Warwick J. Britton
Matt D. Johansen
Laurent Kremer
Stefan H. Oehlers
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

The pathogen Mycobacterium abscessus can switch from a smooth colony form (S) into a highly inflammatory, rough colony form (R) during infection. Here, Kam et al. use an adult zebrafish model of M. abscessus chronic infection to illustrate differences in the immunopathogenesis induced by R and S variants.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723 and 89145259
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.21538f5988d2474e8bf1b3bb89145259
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-28638-5