Inhibition of multi-drug resistant microbial pathogens using an eco-friendly root extract of Furcraea foetida mediated silver nanoparticles

Objectives: Advancement in the biological process of nanoparticles synthesis is an important area of nanotechnology. The aim of this research is to utilize the root extract of Furcraea foetida as reduction and stabilization agents to biosynthesize. Silver nanoparticles (AgNPs) from AgNO3 via a simple green method. Methods: By utilizing UV–VIS spectroscopy, FTIR, XRD, Zeta potential, and HR-TEM techniques, the nanoparticles have been characterized. The anti-Candida properties of AgNPs were tested using the well-diffusion method in agar plates against five Candida species. Results: With an average diameter of 15 nm, the produced AgNPs are spherical. They were found to be stable and non-aggregated. The synthesized nanoparticles were active against all the tested organisms and showed better efficacy compared to Amphotericin B in most cases. The highest level of inhibition was found against C. albicans at 100 µg concentration. Conclusion: The results prove that F. foetida is a very good bioreductant and can be used for one-pot synthesis of stable AgNPs with good anti-Candida activity.