Back to Search Start Over

Molecular-oxygen-promoted Cu-catalyzed oxidative direct amidation of nonactivated carboxylic acids with azoles

Authors :
Wen Ding
Shaoyu Mai
Qiuling Song
Source :
Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 2158-2165 (2015)
Publication Year :
2015
Publisher :
Beilstein-Institut, 2015.

Abstract

A copper-catalyzed oxidative direct formation of amides from nonactivated carboxylic acids and azoles with dioxygen as an activating reagent is reported. The azole amides were produced in good to excellent yields with a broad substrate scope. The mechanistic studies reveal that oxygen plays an essential role in the success of the amidation reactions with copper peroxycarboxylate as the key intermediate. Transamidation occurs smoothly between azole amide and a variety of amines.

Details

Language :
English
ISSN :
18605397
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Beilstein Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
edsdoj.20d6badf664b6fa4c3e0b886e2d4b5
Document Type :
article
Full Text :
https://doi.org/10.3762/bjoc.11.233