Contribution of 5-НТ1А and 5-НТ2А serotonin receptors into immunomodulation: Important role of psychoemotional condition

Experiments that were run on male mice of CBA line, immunized by sheep erythrocytes in dose 5 × 108 showed that 5-НТ1А selective agonist of serotonin receptors 8-OH-DPAT (1 mg/kg) causes suppression of immune response among aggressive animals and mice without experience of victories and defeats (control). Introduction of 8-OH-DPAT did not change the reaction of mice with submissive conduct type. Application of 5-НТ1А selective antagonist of WAY100635 receptors (1 mg/kg) caused stimulation of immune response only among submissive mice and animals without experience of victories and defeats. Blockade effect of 5-НТ2А receptors of their selective blocker ketanserin (1 mg/kg) does not depend on the form of animal conduct. The conclusion is made that changing 5-НТ1А and 5-НТ2А receptor activity leads to different effect on immune response among mice of CBA line depending on initial psychoemotional condition of animals that among aggressive and submissive ones is conditioned by different activity of neurotransmitter system, 5-НТ group in particular.