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Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
- Source :
- Vaccines, Vol 10, Iss 7, p 1136 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination.
- Subjects :
- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
COVID-19 vaccination
multisystem inflammatory syndrome in children (MIS-C)
multisystem inflammatory syndrome following SARS-CoV-2 vaccination (MIS-V)
mild encephalitis/encephalopathy with reversible splenial lesion (MERS)
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 2076393X
- Volume :
- 10
- Issue :
- 7
- Database :
- Directory of Open Access Journals
- Journal :
- Vaccines
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.2060654c0663424480e8617609faedf5
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/vaccines10071136