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Aminocatalytic stereoselective synthesis of (E)-α-naphthyl enals via cross-coupling-like reaction of 1-bromo-2-naphthols with enals
- Source :
- Green Synthesis and Catalysis, Vol 2, Iss 4, Pp 377-380 (2021)
- Publication Year :
- 2021
- Publisher :
- KeAi Communications Co. Ltd., 2021.
-
Abstract
- A diphenyl prolinol TMS ether-catalyzed stereoselective reaction of 1-bromo-2-naphthols with enals has been developed. The organocatalyzed cross coupling-like reaction servers an efficient approach to sterically congested (E)-α-naphthyl enals. The formal C(sp2)-C(sp2) cross-coupling products are obtained in good yields and with excellent stereoselectivities in favor of E-isomers. A broad range of aromatic enals and 1-bromo-2-naphthols are tolerated. The synthetic strategy significantly expands the scope of the organocatalytic cross-coupling-like reactions by enabling sterically demanding 1-bromo-2-naphthols as viable substrates.
Details
- Language :
- English
- ISSN :
- 26665549
- Volume :
- 2
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Green Synthesis and Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.204a794a4c7b4bd6bbb18ac65981c9a0
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.gresc.2021.08.001