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Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern

Authors :
Donal T. Skelly
Adam C. Harding
Javier Gilbert-Jaramillo
Michael L. Knight
Stephanie Longet
Anthony Brown
Sandra Adele
Emily Adland
Helen Brown
Medawar Laboratory Team
Tom Tipton
Lizzie Stafford
Alexander J. Mentzer
Síle A. Johnson
Ali Amini
OPTIC (Oxford Protective T cell Immunology for COVID-19) Clinical Group
Tiong Kit Tan
Lisa Schimanski
Kuan-Ying A. Huang
Pramila Rijal
PITCH (Protective Immunity T cells in Health Care Worker) Study Group
C-MORE/PHOSP-C Group
John Frater
Philip Goulder
Christopher P. Conlon
Katie Jeffery
Christina Dold
Andrew J. Pollard
Alex Sigal
Tulio de Oliveira
Alain R. Townsend
Paul Klenerman
Susanna J. Dunachie
Eleanor Barnes
Miles W. Carroll
William S. James
Source :
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Publication Year :
2021
Publisher :
Nature Portfolio, 2021.

Abstract

Understanding the effect of vaccination on emerging SARS-CoV-2 variants of concern is of increasing importance. Here, James et al. report that two doses of vaccination with the Pfizer-BioNTech vaccine induce more robust immune responses to the B.1.1.7 and B.1.351 SARS-CoV-2 lineages than does natural infection.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
12
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.2028f3a39a5c4516bfd1ae04c2a4f499
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-021-25167-5