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Atypical cadherin, Fat2, regulates axon terminal organization in the developing Drosophila olfactory receptor neurons

Authors :
Khanh M. Vien
Qichen Duan
Chun Yeung
Scott Barish
Pelin Cayirlioglu Volkan
Source :
iScience, Vol 27, Iss 7, Pp 110340- (2024)
Publication Year :
2024
Publisher :
Elsevier, 2024.

Abstract

Summary: The process of how neuronal identity confers circuit organization is intricately related to the mechanisms underlying neurodegeneration and neuropathologies. Modeling this process, the olfactory circuit builds a functionally organized topographic map, which requires widely dispersed neurons with the same identity to converge their axons into one a class-specific neuropil, a glomerulus. In this article, we identified Fat2 (also known as Kugelei) as a regulator of class-specific axon organization. In fat2 mutants, axons belonging to the highest fat2-expressing classes present with a more severe phenotype compared to axons belonging to low fat2-expressing classes. In extreme cases, mutations lead to neural degeneration. Lastly, we found that Fat2 intracellular domain interactors, APC1/2 (Adenomatous polyposis coli) and dop (Drop out), likely orchestrate the cytoskeletal remodeling required for axon condensation. Altogether, we provide a potential mechanism for how cell surface proteins’ regulation of cytoskeletal remodeling necessitates identity specific circuit organization.

Details

Language :
English
ISSN :
25890042
Volume :
27
Issue :
7
Database :
Directory of Open Access Journals
Journal :
iScience
Publication Type :
Academic Journal
Accession number :
edsdoj.1fa88e966e174c2a9d7b2086952ae28b
Document Type :
article
Full Text :
https://doi.org/10.1016/j.isci.2024.110340