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The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges

The role and application of vesicles in triple-negative breast cancer: Opportunities and challenges

Authors :
Ya-Nan Wei
Chun-Yan Yan
Meng-Lu Zhao
Xi-He Zhao
Source :
Molecular Therapy: Oncolytics, Vol 31, Iss , Pp 100752- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Extracellular vesicles (EVs) carry DNA, RNA, protein, and other substances involved in intercellular crosstalk and can be used for the targeted delivery of drugs. Triple-negative breast cancer (TNBC) is rich in recurrent and metastatic disease and lacks therapeutic targets. Studies have proved the role of EVs in the different stages of the genesis and development of TNBC. Cancer cells actively secrete various biomolecules, which play a significant part establishing the tumor microenvironment via EVs. In this article, we describe the roles of EVs in the tumor immune microenvironment, metabolic microenvironment, and vascular remodeling, and summarize the application of EVs for objective delivery of chemotherapeutic drugs, immune antigens, and cancer vaccine adjuvants. EVs-based therapy may represent the next-generation tool for targeted drug delivery for the cure of a variety of diseases lacking effective drug treatment.

Details

Language :
English
ISSN :
23727705
Volume :
31
Issue :
100752-
Database :
Directory of Open Access Journals
Journal :
Molecular Therapy: Oncolytics
Publication Type :
Academic Journal
Accession number :
edsdoj.1f8dc8db2b564f5b99d1011e26376845
Document Type :
article
Full Text :
https://doi.org/10.1016/j.omto.2023.100752