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Pathogenic role of PFKFB3 in endothelial inflammatory diseases

Authors :
Ling Zhou
Juan Li
Juanjuan Wang
Xuping Niu
Junqin Li
Kaiming Zhang
Source :
Frontiers in Molecular Biosciences, Vol 11 (2024)
Publication Year :
2024
Publisher :
Frontiers Media S.A., 2024.

Abstract

The differentiation of vascular endothelial cells and the formation of new blood vessels are inseparable from the energy supply and regulation of metabolism. The budding of blood vessels is a starting point of glycolysis pathway in angiogenesis. Phosphofructokinase-2/fructose 2,6-biophosphatase 3 (PFKFB3), a key rate-limiting enzyme in glycolysis, exhibits strong kinase activity. Inhibition of PFKFB3 can reduce the rate of glycolysis, thereby inhibiting the budding of blood vessels, resulting in inhibition of pathological angiogenesis. In this review, the role of PFKFB3 in the angiogenesis of inflammatory diseases was summarized, and the endothelial inflammatory diseases associated with PFKFB3 were reviewed.

Details

Language :
English
ISSN :
2296889X
Volume :
11
Database :
Directory of Open Access Journals
Journal :
Frontiers in Molecular Biosciences
Publication Type :
Academic Journal
Accession number :
edsdoj.1f5bec94b96434faf2dcaf8558fabea
Document Type :
article
Full Text :
https://doi.org/10.3389/fmolb.2024.1454456