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VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- Mitochondria defects caused by mutant huntingtin (mtHtt) have been implicated in Huntington's disease. Here authors show that VCP binds to mtHtt on the mitochondria, and that treatment with a peptide that disrupts this interaction reduces the cellular and behavioural deficits in mouse models of HD.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1f55ff619f9e46718fcb0202f07879be
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms12646