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Successful Treatment of Cutaneous Protothecosis Due to Prototheca wickerhamii with Terbinafine
- Source :
- Clinical, Cosmetic and Investigational Dermatology, Vol Volume 17, Pp 913-919 (2024)
- Publication Year :
- 2024
- Publisher :
- Dove Medical Press, 2024.
-
Abstract
- Yue Chen,1,* Aili Gao,1,* Yanan Ke,1 Xin Zhou,1 Li Lin,2 Sha Lu,2 Yumei Liu1 1Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, 510095, People’s Republic of China; 2Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, 510120, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yumei Liu, Director of Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, People’s Republic of China, Tel/Fax +86- 20-83593472, Email liuyumei1109@163.comAbstract: Protothecosis, an infrequent human infection, is caused by achlorophyllic algae belonging to the genus Prototheca, particularly Prototheca wickerhamii. The skin stands as the most commonly affected organ. This report documents a case involving an 82-year-old male with Protothecosis. Histopathological analysis revealed granulomatous inflammation in the dermis, exhibiting necrotic features and hosting numerous non-budding spherical organisms. These organisms were positively stained using methenamine silver and periodic acid–Schiff stains, confirming identification as P. wickerhamii after validation through tissue culture and sequencing procedures. Initially, the patient received oral itraconazole at a dosage of 200 mg daily, accompanied by topical 1% naftifine-0.25% ketoconazole cream for a duration of 4 weeks, resulting in significant improvement. Subsequently, due to gastrointestinal discomfort presumably linked to itraconazole, terbinafine was administered. Over a span of 3 months, the patient received oral terbinafine at a dosage of 250 mg/day alongside the application of topical 1% naftifine-0.25% ketoconazole cream, leading to complete healing of the skin lesion, leaving behind a fibrotic scar.Keywords: protothecosis, Prototheca wickerhamii, terbinafine
- Subjects :
- protothecosis
prototheca wickerhamii
terbinafine.
Dermatology
RL1-803
Subjects
Details
- Language :
- English
- ISSN :
- 11787015
- Volume :
- ume 17
- Database :
- Directory of Open Access Journals
- Journal :
- Clinical, Cosmetic and Investigational Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1f330ca08835474f8b7e05a13c1f3b1a
- Document Type :
- article