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Susceptibility pattern of enterococci at tertiary care hospital

Authors :
Sadhana Sachan
Vinita Rawat
Umesh
Mukesh Kumar
Tripta Kaur
Preeti Chaturvedi
Source :
Journal of Global Infectious Diseases, Vol 9, Iss 2, Pp 73-75 (2017)
Publication Year :
2017
Publisher :
Wolters Kluwer Medknow Publications, 2017.

Abstract

The study was aimed to characterize enterococci from various clinical specimens, to determine the antimicrobial susceptibility pattern, and to explore the association between virulence factors and antimicrobial resistance. A total of 283 clinical enterococcal isolates were speciated and subjected to antimicrobial susceptibility testing. Virulence factors (hemolysin, gelatinase, and biofilm production) were detected phenotypically. Of the 283 enterococci isolated, 12 species were identified; predominant species were Enterococcus faecalis (82.33%). High-level gentamicin (HLG) and vancomycin resistance were observed among 55.57% and 6.01% of enteroccal isolates, respectively. All vancomycin-resistant enterococci (VREs) were E. faecalis and had VanA phenotype and genotype. Hemolysin, gelatinase, and biofilm production were seen in 15.90%, 12.36%, and 13.43% of enterococcal isolates, respectively. Vancomycin and HLG resistance were observed in 0.35% and 61.86% of the enterococcal isolates producing virulence factors. Isolates resistant to HLG but susceptible to vancomycin expressed more virulent factors. Further research is required to reveal the complex interplay between drug resistance and virulence factors.

Details

Language :
English
ISSN :
0974777X
Volume :
9
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Journal of Global Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.1f04b7535c4f69bc754db9367a9798
Document Type :
article
Full Text :
https://doi.org/10.4103/0974-777X.194371