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Circadian Clock Regulation of Hepatic Energy Metabolism Regulatory Circuits
- Source :
- Biology, Vol 8, Iss 4, p 79 (2019)
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- The liver is a critical organ of energy metabolism. At least 10% of the liver transcriptome demonstrates rhythmic expression, implying that the circadian clock regulates large programmes of hepatic genes. Here, we review the mechanisms by which this rhythmic regulation is conferred, with a particular focus on the transcription factors whose actions combine to impart liver- and time-specificity to metabolic gene expression.
Details
- Language :
- English
- ISSN :
- 20797737
- Volume :
- 8
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- Biology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1ecbdaf4c0c540ce9b1becbdb96904e6
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/biology8040079