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Gut microbiome dysbiosis in antibiotic-treated COVID-19 patients is associated with microbial translocation and bacteremia

Authors :
Lucie Bernard-Raichon
Mericien Venzon
Jon Klein
Jordan E. Axelrad
Chenzhen Zhang
Alexis P. Sullivan
Grant A. Hussey
Arnau Casanovas-Massana
Maria G. Noval
Ana M. Valero-Jimenez
Juan Gago
Gregory Putzel
Alejandro Pironti
Evan Wilder
Yale IMPACT Research Team
Lorna E. Thorpe
Dan R. Littman
Meike Dittmann
Kenneth A. Stapleford
Bo Shopsin
Victor J. Torres
Albert I. Ko
Akiko Iwasaki
Ken Cadwell
Jonas Schluter
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Here, the authors show that SARS-CoV-2 infection causes gut microbiome dysbiosis and gut epithelial cell alterations in a mouse model, and correlate dysbiosis observed in COVID-19 patients with blood stream infections, matching reads of bacterial sequences from stool samples to organisms found in the blood.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1e9e329dabff4d05a3ee9e3f9ac67097
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-33395-6