Cost-effectiveness of reflex laboratory-based cryptococcal antigen screening for the prevention and treatment of cryptococcal meningitis in Botswana [version 1; peer review: 2 approved]

Authors :: Mark W. Tenforde
Charles Muthoga
Andrew Callaghan
Ponego Ponetshego
Julia Ngidi
Madisa Mine
Alexander Jordan
Tom Chiller
Bruce A. Larson
Joseph N. Jarvis
Source :: Wellcome Open Research, Vol 4 (2019)
Publication Year :: 2019
Publisher :: Wellcome, 2019.
Abstract: Background: Cryptococcal antigen (CrAg) screening for antiretroviral therapy (ART)-naïve adults with advanced HIV/AIDS can reduce the incidence of cryptococcal meningitis (CM) and all-cause mortality. We modeled the cost-effectiveness of laboratory-based “reflex” CrAg screening for ART-naïve CrAg-positive patients with CD4

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