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Serological Outcome in the First Months of Life of Children Born to Mothers with SARS-CoV-2 Infection during Pregnancy

Authors :
Gemma Pons-Tomàs
Irene Martínez-de-Albeniz
María Ríos-Barnés
Anna Gamell
Sílvia Simó-Nebot
Sol Balsells-Mejía
María Hernández-García
Maria Melé-Casas
Emilia Sánchez
Manuel Monsonis
Amadeu Gené
Marta López
Dolors Salvia
Juan-José Garcia-García
Claudia Fortuny
Victoria Fumadó
Source :
Children, Vol 11, Iss 9, p 1095 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

Background: The objective of this study is to analyze the transplacental transmission of SARS-CoV-2 antibodies, their persistence in newborns, the factors that may influence this transmission, and the protection these antibodies confer over time. Methods: This prospective cohort was conducted in a tertiary pediatric hospital in the Barcelona Metropolitan Region, Spain. It included neonates born to mothers who had SARS-CoV-2 infection during pregnancy or delivery between August 2020 and January 2022. We followed the recruited children for at least six months, and blood tests were performed to determine the presence of SARS-CoV-2 antibodies. Results: A total of 101 children were recruited. Among the serologies performed on children under three months of age, 44/82 were positive (53.7%). Newborns whose mothers presented more severe disease exhibited higher seropositivity odds (coefficient 9.747; p = 0.002). There were increased preterm deliveries when maternal infection occurred closer to the time of delivery. No severe SARS-CoV-2 infections were detected in children during the follow-up. Conclusions: Slightly more than half of the SARS-CoV-2 serologies performed in the first three months were positive. This appears to confer protection during early childhood. The severity of maternal infection is the most significant factor influencing the transmission of antibodies in children born to unvaccinated mothers.

Details

Language :
English
ISSN :
22279067
Volume :
11
Issue :
9
Database :
Directory of Open Access Journals
Journal :
Children
Publication Type :
Academic Journal
Accession number :
edsdoj.1e1b71d0d1f64247bc85f2642cac5412
Document Type :
article
Full Text :
https://doi.org/10.3390/children11091095