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Metamizole (dipyrone) – cytotoxic and antiproliferative effects on HeLa, HT-29 and MCF-7 cancer cell lines

Metamizole (dipyrone) – cytotoxic and antiproliferative effects on HeLa, HT-29 and MCF-7 cancer cell lines

Authors :
Irina Nikolova
Lyubomir Marinov
Ani Georgieva
Reneta Toshkova
Martin Malchev
Yulian Voynikov
Ivanka Kostadinova
Source :
Biotechnology & Biotechnological Equipment, Vol 32, Iss 5, Pp 1327-1337 (2018)
Publication Year :
2018
Publisher :
Taylor & Francis Group, 2018.

Abstract

Cancer pain treatment is a big challenge for healthcare providers and patients as well. The wide range of non-steroidal anti-inflammatory drugs (NSAIDs) used as painkillers in cancer patients, requires in-depth characterization of their effect on the disease process. The effects of NSAIDs have been widely studied over the last decades as preventive drugs in some oncological diseases. Metamizole is an NSAID belonging to the non-narcotic analgesics group and is highly recommended in oncology either alone or in combinations with opioid analgesics. There is a dearth of information regarding the cytotoxicity profile of metamizole and hence the present study evaluated the potential anticancer activity of metamizole in some permanent human tumour cell lines: HeLa, human cervical cancer cells; HT-29, a human colorectal adenocarcinoma cell line; and МСF-7, human breast adenocarcinoma cells. The studied tumour cells were sensitive to metamizole at doses higher than 25 μg/mL. Metamizole induced a statistically significant decrease in the viability of HeLa, HT-29 and MCF-7 cells in in vitro tests as measured by the MTT assay; the highest effect was observed at the 48th hour of the treatment. Metamizole could induce cell death by apoptosis. Metamizole also suppressed the migration of the three tumour cell lines. This was most clearly pronounced in HeLa cells. The results obtained indicate that metamizole is a suitable choice for the treatment of cancer pain and has prospects for further in-depth studies.

Details

Language :
English
ISSN :
13102818 and 13143530
Volume :
32
Issue :
5
Database :
Directory of Open Access Journals
Journal :
Biotechnology & Biotechnological Equipment
Publication Type :
Academic Journal
Accession number :
edsdoj.1ded3b1832874cafafaba32a5c5e46a2
Document Type :
article
Full Text :
https://doi.org/10.1080/13102818.2018.1511382