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Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation

Respiratory viral infections in pediatric patients with hematopoietic stem cell transplantation

Authors :
José F. Gaytán-Morales
Iván Castorena-Villa
Dolores C. Cortés-Flores
Martha J. Avilés-Robles
José L. Sánchez-Huerta
Vianney Ortiz-Navarrete
Irlanda Olvera-Gómez
Briceida López-Martínez
Israel Parra-Ortega
Source :
Boletín Médico del Hospital Infantil de México, Vol 78, Iss 3 (2021)
Publication Year :
2021
Publisher :
Permanyer, 2021.

Abstract

Background: Viral respiratory infections in pediatric patients with hematopoietic stem cell transplantation (HSCT) significantly impact morbidity and mortality. It is necessary to determine the viral agents and their frequency of presentation to understand their impact on transplantation patients’ evolution. Methods: From January 2017 to December 2019, we conducted a cross-sectional, descriptive, and observational study of patients who underwent HSCT with a viral respiratory infection. Viral identification was performed using multiplex polymerase chain reaction for nine respiratory viruses. Descriptive statistics were performed with a report of central tendency measures and percentages. Results: Of the 54 pediatric patients who underwent HSCT, 59.2% presented an airway infection; in turn, at least one viral agent was identified in 59.3% of these patients. The most frequent viral agents were influenza (25.9%), human rhinovirus (18.5%), and respiratory syncytial virus (18.5%). Viral co-infections occurred in 36.8% of the cases. The reported complications were supplemental oxygen requirement (73.6%), support with mechanical ventilation (21%), admission to the pediatric intensive care unit (15.7%), and mortality associated with a viral respiratory infection (10.5%). Conclusions: Viral respiratory infections are frequent in pediatric patients with HSCT; influenza A/B virus was the most frequent agent. As morbidity and mortality increase due to these infections in patients with HSCT, strategies are necessary for its prevention and timely treatment after transplantation.

Details

Language :
English, Spanish; Castilian
ISSN :
05396115 and 47879378
Volume :
78
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Boletín Médico del Hospital Infantil de México
Publication Type :
Academic Journal
Accession number :
edsdoj.1dcbfe99bb1f47879378d2d118adce5e
Document Type :
article
Full Text :
https://doi.org/10.24875/BMHIM.20000126