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The rapid and highly parallel identification of antibodies with defined biological activities by SLISY

Authors :
Steve Lu
Austin K. Mattox
P. Aitana Azurmendi
Ilias Christodoulou
Katharine M. Wright
Maria Popoli
Zan Chen
Surojit Sur
Yana Li
Challice L. Bonifant
Chetan Bettegowda
Nickolas Papadopoulos
Shibin Zhou
Sandra B. Gabelli
Bert Vogelstein
Kenneth W. Kinzler
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

The covid pandemic has highlighted the need for rapid antibody development. Here, authors develop an approach called SLISY, which uses NGS with phage display to simultaneously assess millions of clones to rapidly isolate specific antibodies against SARS-CoV-2 and its evolving variants.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1dcb103877994cf8b3292eb0a55e545d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-35668-6