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Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms

Authors :
Yunzhi Wang
Rongkui Luo
Xuan Zhang
Hang Xiang
Bing Yang
Jinwen Feng
Mengjie Deng
Peng Ran
Akesu Sujie
Fan Zhang
Jiajun Zhu
Subei Tan
Tao Xie
Pin Chen
Zixiang Yu
Yan Li
Dongxian Jiang
Xiaobiao Zhang
Jian-Yuan Zhao
Yingyong Hou
Chen Ding
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-32 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

The proteogenomic landscape of diffuse gliomas remains to be explored. Here, the authors perform proteogenomic characterisation of diffuse gliomas, investigate the functional role of genomic alterations and suggest three proteomic subgroups.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1d9161a18c684bffaa32bb2b98621ff1
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36005-1