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Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

Authors :
Piotr Celichowski
Marcello Turi
Sandra Charvátová
Dhwani Radhakrishnan
Neda Feizi
Zuzana Chyra
Michal Šimíček
Tomáš Jelínek
Juli Rodriguez Bago
Roman Hájek
Matouš Hrdinka
Source :
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-23 (2023)
Publication Year :
2023
Publisher :
BMC, 2023.

Abstract

Abstract Cancer immunotherapies utilizing genetically engineered T cells have emerged as powerful personalized therapeutic agents showing dramatic preclinical and clinical results, particularly in hematological malignancies. Ectopically expressed chimeric antigen receptors (CARs) reprogram immune cells to target and eliminate cancer. However, CAR T cell therapy's success depends on the balance between effective anti-tumor activity and minimizing harmful side effects. To improve CAR T cell therapy outcomes and mitigate associated toxicities, scientists from different fields are cooperating in developing next-generation products using the latest molecular cell biology and synthetic biology tools and technologies. The immunotherapy field is rapidly evolving, with new approaches and strategies being reported at a fast pace. This comprehensive literature review aims to provide an up-to-date overview of the latest developments in controlling CAR T cell activity for improved safety, efficacy, and flexibility.

Details

Language :
English
ISSN :
14795876
Volume :
21
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Journal of Translational Medicine
Publication Type :
Academic Journal
Accession number :
edsdoj.1d5b44d5e5a746e6967cb1d46fd3f1a9
Document Type :
article
Full Text :
https://doi.org/10.1186/s12967-023-04041-6