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Asymmetric carbohydroxylation of alkenes via sequential photocatalytic oxo-alkylation and enzymatic reduction
- Source :
- Tetrahedron Chem, Vol 11, Iss , Pp 100083- (2024)
- Publication Year :
- 2024
- Publisher :
- Elsevier, 2024.
-
Abstract
- Asymmetric carbohydroxylation of alkenes offers an efficient approach to access chiral alcohols, a class of versatile building blocks in pharmaceutical and agrochemical industries, from abundant simple alkenes. Herein we reported a sequential photo-biocatalysis protocol for the asymmetric carbohydroxylation of alkenes, involving a stepwise photocatalytic decarboxylative radical addition/Kornblum oxidation and enzymatic reduction. A series of chiral alcohols with bulky structures were synthesized in up to 75 % isolated yields and 99 % ee from N-hydroxyphthalimide esters and aryl alkenes.
Details
- Language :
- English
- ISSN :
- 2666951X and 75002477
- Volume :
- 11
- Issue :
- 100083-
- Database :
- Directory of Open Access Journals
- Journal :
- Tetrahedron Chem
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1d54d1d75002477182a12bef64f5b9ce
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.tchem.2024.100083