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Ascorbic acid metabolites are involved in intraocular pressure control in the general population

Authors :
Pirro G. Hysi
Anthony P. Khawaja
Cristina Menni
Bani Tamraz
Nick Wareham
Kay-Tee Khaw
Paul J. Foster
Leslie Z. Benet
Tim D. Spector
Chris J. Hammond
Source :
Redox Biology, Vol 20, Iss , Pp 349-353 (2019)
Publication Year :
2019
Publisher :
Elsevier, 2019.

Abstract

Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. Mechanisms involved in its homeostasis are not well understood, but associations between metabolic factors and IOP have been reported. To investigate the relationship between levels of circulating metabolites and IOP, we performed a metabolome-wide association using a machine learning algorithm, and then employing Mendelian Randomization models to further explore the strength and directionality of effect of the metabolites on IOP. We show that O-methylascorbate, a circulating Vitamin C metabolite, has a significant IOP-lowering effect, consistent with previous knowledge of the anti-hypertensive and anti-oxidative role of ascorbate compounds. These results enhance understanding of IOP control and may potentially benefit future IOP treatment and reduce vision loss from glaucoma. Keywords: Ascorbate metabolism, Intraocular pressure, Multi-omics

Details

Language :
English
ISSN :
22132317
Volume :
20
Issue :
349-353
Database :
Directory of Open Access Journals
Journal :
Redox Biology
Publication Type :
Academic Journal
Accession number :
edsdoj.1d4a72f081424923b2ccbf836e0ca87a
Document Type :
article
Full Text :
https://doi.org/10.1016/j.redox.2018.10.004