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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance
- Source :
- Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
- Publication Year :
- 2023
- Publisher :
- Nature Portfolio, 2023.
-
Abstract
- The failure of metabolic tissues to respond to insulin is an early marker of type 2 diabetes. Here, the authors show, using global phosphoproteomics, that insulin resistance is caused by a marked rewiring of both canonical and non-canonical insulin signalling, and includes dysregulated GSK3 activity.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 14
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1d1d85eedd7542a2a8117c06e8ff0883
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-023-36549-2