Back to Search Start Over

Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms

Authors :
Kyra-Alexandra Köster
Marten Dethlefs
Jorge Duque Escobar
Elke Oetjen
Source :
Cells, Vol 13, Iss 4, p 333 (2024)
Publication Year :
2024
Publisher :
MDPI AG, 2024.

Abstract

The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12 (MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage kinases, characterized by homology to serine/threonine and tyrosine kinase, but exerts serine/threonine kinase activity. DLK has been implicated in many diseases, including several neurodegenerative diseases, glaucoma, and diabetes mellitus. As a MAP3K, it is generally assumed that DLK becomes phosphorylated and activated by upstream signals and phosphorylates and activates itself, the downstream serine/threonine MAP2K, and, ultimately, MAPK. In addition, other mechanisms such as protein–protein interactions, proteasomal degradation, dephosphorylation by various phosphatases, palmitoylation, and subcellular localization have been shown to be involved in the regulation of DLK activity or its fine-tuning. In the present review, the diverse mechanisms regulating DLK activity will be summarized to provide better insights into DLK action and, possibly, new targets to modulate DLK function.

Details

Language :
English
ISSN :
20734409
Volume :
13
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.1ce1ad77a894886b5f20b2834e04279
Document Type :
article
Full Text :
https://doi.org/10.3390/cells13040333