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Association between coronary artery calcium and cardiovascular disease as a supporting cause in cancer: The CAC consortium
- Source :
- American Journal of Preventive Cardiology, Vol 4, Iss , Pp 100119- (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Background: Identifying cancer patients at high risk of CVD is important for targeting CVD prevention strategies and evaluating chemotherapy options in the context of cardiotoxicity. Coronary artery calcium (CAC), a strong marker of coronary atherosclerosis, is used clinically to enhance risk assessment, yet the value of CAC for assessing risk of CVD complications in cancer is poorly understood. Objective: In cases of cancer mortality, to determine the value of CAC for predicting risk of CVD as a supporting cause of death. Methods: The CAC Consortium is a multi-center cohort of 66,636 asymptomatic adults without CVD who underwent CAC scanning. During a follow-up of 12.5 years, 1129 patients died of cancer and were included in this analysis. The primary outcome was presence of CVD listed as a supporting cause of cancer mortality on official death certificates obtained from the National Death Index. Logistic regression models were used to assess the odds of CVD being listed as a supporting cause of death by CAC. Results: CVD was listed as a supporting cause of death in 306 (27%) cancer mortality cases. Baseline CAC was significantly higher in individuals with CVD-supported mortality. Odds ratios of having CVD-supported death increased by ASCVD risk score category [1.15 (0.81, 1.65) for 5–20% 10-year risk and 1.97 (1.36, 2.89) for ≥20% risk, in reference to
Details
- Language :
- English
- ISSN :
- 26666677
- Volume :
- 4
- Issue :
- 100119-
- Database :
- Directory of Open Access Journals
- Journal :
- American Journal of Preventive Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1cd5e81535cc4e8bb5da96d372650ddc
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ajpc.2020.100119