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Ravuconazole self-emulsifying delivery system: in vitro activity against Trypanosoma cruzi amastigotes and in vivo toxicity
- Source :
- International Journal of Nanomedicine, Vol Volume 12, Pp 3785-3799 (2017)
- Publication Year :
- 2017
- Publisher :
- Dove Medical Press, 2017.
-
Abstract
- Pollyanna Álvaro Spósito,1 Ana Lia Mazzeti,1,2 Caroline de Oliveira Faria,1 Julio A Urbina,3 Gwenaelle Pound-Lana,1 Maria Terezinha Bahia,2 Vanessa Furtado Mosqueira1 1Laboratory of Pharmaceutics and Nanotechnology Research, Pharmacy Department, School of Pharmacy, Universidade Federal de Ouro Preto, Minas Gerais, Brazil; 2Parasite Diseases Research Laboratory, NUPEB, Medical School, Universidade Federal de Ouro Preto, MG, Brazil; 3Venezuelan Institute for Scientific Research, Apartado, Caracas, Venezuela Abstract: Self-emulsifying drug delivery systems (SEDDSs) are lipid-based anhydrous formulations composed of an isotropic mixture of oil, surfactant, and cosurfactants usually presented in gelatin capsules. Ravuconazole (Biopharmaceutics Classification System [BCS] Class II) is a poorly water-soluble drug, and a SEDDS type IIIA was designed to deliver it in a predissolved state, improving dissolution in gastrointestinal fluids. After emulsification, the droplets had mean hydrodynamic diameters
Details
- Language :
- English
- ISSN :
- 11782013
- Volume :
- ume 12
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1cc94e244de445e0acfe79c2367a7d2d
- Document Type :
- article