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Edible‐plant derived 2′,4′‐dihydroxy‐6′‐methoxy‐3′,5′‐dimethylchalcone exert dual effects on invigorating triple‐negative breast cancer apoptosis

Authors :
Tingting Yu
Yu Jiang
Miaomiao Guo
Xing Wei
Xiujuan Xin
Faliang An
Source :
Food Bioengineering, Vol 3, Iss 2, Pp 222-235 (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Abstract 2′,4′‐Dihydroxy‐6′‐methoxy‐3′,5′‐dimethylchalcone (DMC) is a typical and abundant chalcone compound from the buds of Cleistocalyx operculatus, which is well‐known for its edible and medicinal qualities. In this study, DMC showed effective cell cycle arrest at G2/M on MDA‐MB‐231 cells, though dual impacts, including the inhibition of microtubule polymerization through binding to β‐tubulin and the stimulation of reactive oxygen species (ROS) production by inhibiting catalase activity. The increased ROS level inhibited PI3K/Akt/mTOR pathway and further suppressed the expression level of Cdc2, Cdc25C, and Cyclin B1, alongside stimulated the expression level of p21 and p27. Above 29.5% MDA‐MB‐231 cells were arrested at G2/M phase, subsequently undergoing apoptosis due to heightened levels of apoptosis‐related proteins Bax and caspase 3. In summary, this study demonstrated that DMC concomitantly plays dual roles in apoptotic inducing by inhibiting the ROS consumption and microtubules formation in triple‐negative breast cancer cells.

Details

Language :
English
ISSN :
27702081
Volume :
3
Issue :
2
Database :
Directory of Open Access Journals
Journal :
Food Bioengineering
Publication Type :
Academic Journal
Accession number :
edsdoj.1cc31edf10bb48d594976d5cfe2e3231
Document Type :
article
Full Text :
https://doi.org/10.1002/fbe2.12092