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Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?

Authors :
Jessica Rossi
Francesco Cavallieri
Giuseppe Biagini
Romana Rizzi
Marco Russo
Salvatore Cozzi
Lucia Giaccherini
Anna Pisanello
Franco Valzania
Source :
Medicina, Vol 58, Iss 10, p 1349 (2022)
Publication Year :
2022
Publisher :
MDPI AG, 2022.

Abstract

Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, γ-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic.

Details

Language :
English
ISSN :
58101349, 16489144, and 1010660X
Volume :
58
Issue :
10
Database :
Directory of Open Access Journals
Journal :
Medicina
Publication Type :
Academic Journal
Accession number :
edsdoj.1c4b0e9bc298452e99046bc2d45aa466
Document Type :
article
Full Text :
https://doi.org/10.3390/medicina58101349