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Epileptogenesis and Tumorigenesis in Glioblastoma: Which Relationship?
- Source :
- Medicina, Vol 58, Iss 10, p 1349 (2022)
- Publication Year :
- 2022
- Publisher :
- MDPI AG, 2022.
-
Abstract
- Epilepsy is reported in 29–52% of patients with glioblastoma (GBM) and has an important role in the natural history of this tumor and patients’ life quality. Although GBM is less epileptogenic than lower-grade gliomas, seizures are usually more difficult to control with common antiseizure medications; drug resistance is found in 20% of cases. Recent studies suggest that seizures at the onset of GBM could be a possible favorable independent prognostic factor in patients. Moreover, a growing body of evidence shows that many molecular mechanisms that influence epileptogenesis often regulate GBM growth and invasiveness, sometimes favoring or counteracting the tumor, respectively. The better-characterized players include glutamate, γ-aminobutyric acid, aquaporin-4, and hypoxia-activated molecules. However, currently available data on the molecular basis of epileptogenesis, tumorigenesis, and their relationship is incomplete or discordant and further research is urgently needed on this topic.
Details
- Language :
- English
- ISSN :
- 58101349, 16489144, and 1010660X
- Volume :
- 58
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Medicina
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1c4b0e9bc298452e99046bc2d45aa466
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/medicina58101349