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Malignant epithelioid mesothelioma in senile Red Sindhi cows from Brazil

Authors :
Mariana C. Oliveira
Ileana Miranda
Yasmin Daoualibi
Samara P. Lopes
Asheley H.B. Pereira
Bruno G. Souza
Tatiane T. Negrão Watanabe
Aníbal G. Armién
Daniel G. Ubiali
Marilene F. Brito
Source :
Pesquisa Veterinária Brasileira, Vol 43 (2023)
Publication Year :
2023
Publisher :
Colégio Brasileiro de Patologia Animal (CBPA), 2023.

Abstract

ABSTRACT: Mesotheliomas in cattle are often described as isolated case reports, and investigations of multiple cases within the same bovine herd are lacking. A series of cases of malignant epithelial mesothelioma, tubulopapilary type, is described in five 15 to 21-year-old Red Sindhi cows from the same herd. Clinical signs included three to eight months of progressive emaciation, dehydration, subcutaneous edema of the lower extremities, and abdominal distension. Grossly, severe subcutaneous edema and hydroperitoneum were noted. Multiple organs’ parietal and visceral serosal surfaces had multifocal to coalescing yellow, firm, sessile nodules ranging from 0.1 to 29.0cm. Similar free nodules floated in the peritoneal fluid. Histologically, the masses comprised a layer of cubic to columnar neoplastic cells forming papillary or cystic proliferation supported by a dense fibrovascular stroma. Neoplastic cells had strong and diffuse cytoplasmic immunolabeling for pan-cytokeratin but were negative for cytokeratin 7 and vimentin. Ultrastructurally, neoplastic cells had delicate microvilli and tight and anchoring junctions. Within the cytoplasm, a moderate amount of loose aggregate of intermediary filament with small mitochondria was observed. Epidemiological investigation evidenced endogamy in this herd. Asbestos exposure was not detected. The diagnosis was based on clinical, gross, histological, and immunohistochemical findings and confirmed by transmission electron microscopy features. A definitive underlying etiology remains unknown.

Details

Language :
English, Portuguese
ISSN :
16785150
Volume :
43
Database :
Directory of Open Access Journals
Journal :
Pesquisa Veterinária Brasileira
Publication Type :
Academic Journal
Accession number :
edsdoj.1c3c28119daf4bd6bda6332dacb2e308
Document Type :
article
Full Text :
https://doi.org/10.1590/1678-5150-pvb-7279