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Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Authors :
Julia Ast
Anastasia Arvaniti
Nicholas H. F. Fine
Daniela Nasteska
Fiona B. Ashford
Zania Stamataki
Zsombor Koszegi
Andrea Bacon
Ben J. Jones
Maria A. Lucey
Shugo Sasaki
Daniel I. Brierley
Benoit Hastoy
Alejandra Tomas
Giuseppe D’Agostino
Frank Reimann
Francis C. Lynn
Christopher A. Reissaus
Amelia K. Linnemann
Elisa D’Este
Davide Calebiro
Stefan Trapp
Kai Johnsson
Tom Podewin
Johannes Broichhagen
David J. Hodson
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics in islets and brain.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1bec881e08194ff3b4ad84658e067529
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-14309-w