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Integrated analysis of the lncRNA-associated competing endogenous RNA network in salt sensitivity of blood pressure

Authors :
Wenjuan Peng
Yunyi Xie
Juan Xia
Han Qi
Kuo Liu
Bingxiao Li
Fengxu Zhang
Fuyuan Wen
Ling Zhang
Source :
Heliyon, Vol 9, Iss 12, Pp e22466- (2023)
Publication Year :
2023
Publisher :
Elsevier, 2023.

Abstract

Accumulating evidence showed that competing endogenous RNA (ceRNA) mechanism plays a pivotal role in salt sensitivity of blood pressure (SSBP). We constructed a ceRNA network based on SSBP-related differently expressed lncRNAs (2), mRNAs (73) and miRNAs (18). Bioinformatic analyses were utilized to analyze network and found network genes participate in biological pathways related to SSBP pathogenesis such as regulation of nitric oxide biosynthetic process (GO:0045,428) and cellular response to cytokine stimulus (GO:0071,345). Fourteen candidate ceRNA pathways were selected from network to perform qRT-PCR validation and found nine RNAs (KCNQ1OT1, SLC8A1-AS1, IL1B, BCL2L11, KCNJ15, CX3CR1, KLF2, hsa-miR-362–5p and hsa-miR-423–5p) differently expressed between salt-sensitive (SS) and salt-resistant (SR) groups (P

Details

Language :
English
ISSN :
24058440
Volume :
9
Issue :
12
Database :
Directory of Open Access Journals
Journal :
Heliyon
Publication Type :
Academic Journal
Accession number :
edsdoj.1bc263670a8248eeaa48249f225efe33
Document Type :
article
Full Text :
https://doi.org/10.1016/j.heliyon.2023.e22466