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Crystal structures of the human elongation factor eEFSec suggest a non-canonical mechanism for selenocysteine incorporation

Authors :
Malgorzata Dobosz-Bartoszek
Mark H. Pinkerton
Zbyszek Otwinowski
Srinivas Chakravarthy
Dieter Söll
Paul R. Copeland
Miljan Simonović
Source :
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Publication Year :
2016
Publisher :
Nature Portfolio, 2016.

Abstract

Specialized translation elongation factors (eEFSec and SelB) promote selenocysteine incorporation into proteins. Here, the authors report the structure of human eEFSec, examine its interactions with guanine nucleotides, and propose a non-canonical mechanism for decoding selenocysteine.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
7
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1bc117eaac2c4b32ae01b3db056620d1
Document Type :
article
Full Text :
https://doi.org/10.1038/ncomms12941