The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

Authors :: Sensen Zhang
Jun Zhou
Yuebin Zhang
Tianya Liu
Perrine Friedel
Wei Zhuo
Suma Somasekharan
Kasturi Roy
Laixing Zhang
Yang Liu
Xianbin Meng
Haiteng Deng
Wenwen Zeng
Guohui Li
Biff Forbush
Maojun Yang
Source :: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Publication Year :: 2021
Publisher :: Nature Portfolio, 2021.
Abstract: Zhang et al. present the cryo-electron microscopy structures of the two neuronal cation-chloride cotransporters human NKCC1 and mouse KCC2, identifying their essential residues for ion transport. This study proposes mechanisms by which phosphorylation regulates the activity of these cation-chloride cotransporters.

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