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Lipoprotein(a) Modulates Carotid Atherosclerosis in Metabolic Syndrome

Authors :
Anna Laura Cremonini
Andrea Pasta
Federico Carbone
Luca Visconti
Matteo Casula
Edoardo Elia
Aldo Bonaventura
Luca Liberale
Maria Bertolotto
Nathan Artom
Silvia Minetti
Paola Contini
Daniela Verzola
Roberto Pontremoli
Francesca Viazzi
Giorgio Luciano Viviani
Stefano Bertolini
Aldo Pende
Fabrizio Montecucco
Livia Pisciotta
Source :
Frontiers in Molecular Biosciences, Vol 9 (2022)
Publication Year :
2022
Publisher :
Frontiers Media S.A., 2022.

Abstract

Background and Aim: High lipoprotein(a) [Lp(a)] is a well-established cardiovascular (CV) risk factor, but the effect of mildly elevated Lp(a) on CV health is largely unknown. Our aim was to evaluate if Lp(a) is associated with the severity of carotid atherosclerosis (CA) in the specific subset of metabolic syndrome (MetS).Patients and Methods: Subjects with diagnosed MetS and ultrasound-assessed CA were enrolled. Those patients were categorized according to the severity of CA (moderate vs. severe), and the circulating levels of Lp(a) alongside with clinical, anthropometric, and biochemical data were collected.Results: Sixty-five patients were finally included: twenty-five with moderate and forty with severe CA (all with asymptomatic disease). Intergroup comparison showed Lp(a) as the only significantly different variable [6 (2–12) mg/dl vs. 11.5 (6–29.5) mg/dl; p = 0.018]. Circulating levels of Lp(a) were also confirmed as the only variable independently associated with severity of CA at logistic regression analysis [OR 2.9 (95% CI 1.1–7.8); p = 0.040]. ROC curve analysis for Lp(a) confirmed a serum level of 10 mg/dl as the best cut-off value [AUC 0.675 (95% CI 0.548–0.786)]. Although sensitivity and specificity were suboptimal (69.0 and 70.4%, respectively)—likely due to the small sample size—this result is in line with those previously reported in the literature.Conclusion: Lp(a) is independently associated with severity of CA in the subgroup of MetS patients.

Details

Language :
English
ISSN :
2296889X
Volume :
9
Database :
Directory of Open Access Journals
Journal :
Frontiers in Molecular Biosciences
Publication Type :
Academic Journal
Accession number :
edsdoj.1b5685523d594be69391fc489b7d0d84
Document Type :
article
Full Text :
https://doi.org/10.3389/fmolb.2022.854624