Back to Search Start Over

Hormographiella aspergillata: an emerging basidiomycete in the clinical setting? A case report and literature review

Authors :
Maxime Moniot
Rose-Anne Lavergne
Thomas Morel
Romain Guieze
Florent Morio
Philippe Poirier
Céline Nourrisson
Source :
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-7 (2020)
Publication Year :
2020
Publisher :
BMC, 2020.

Abstract

Abstract Background Filamentous basidiomycetes are mainly considered to be respiratory tract colonizers but the clinical significance of their isolation in a specimen is debatable. Hormographiella aspergillata was first reported as a human pathogen in 1971. We discuss the role of this mold as a pathogen or colonizer and give an update on diagnostic tools and in vitro antifungal susceptibility. Case presentation We identified three cases of H. aspergillata with respiratory symptoms in a short period of time. One invasive infection and two colonizations were diagnosed. Culture supernatants showed that H. aspergillata can produce galactomannan and β-D-glucan but not glucuronoxylomannan. For the first time, isavuconazole susceptibility was determined and high minimum inhibitory concentrations (MICs) were found. Liposomal amphotericin B and voriconazole have the lowest MICs. Conclusion To date, 22 invasive infections involving H. aspergillata have been reported. On isolation of H. aspergillata, its pathogenic potential in clinical settings can be tricky. Molecular identification and antifungal susceptibility testing are essential considering high resistance against several antifungal therapies.

Details

Language :
English
ISSN :
14712334
Volume :
20
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Infectious Diseases
Publication Type :
Academic Journal
Accession number :
edsdoj.1b5609410acf490fb33a22410dd652b0
Document Type :
article
Full Text :
https://doi.org/10.1186/s12879-020-05679-z