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Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA in humans

Authors :
Wei Wei
Alistair T. Pagnamenta
Nicholas Gleadall
Alba Sanchis-Juan
Jonathan Stephens
John Broxholme
Salih Tuna
Christopher A. Odhams
Genomics England Research Consortium
NIHR BioResource
Carl Fratter
Ernest Turro
Mark J. Caulfield
Jenny C. Taylor
Shamima Rahman
Patrick F. Chinnery
Source :
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Publication Year :
2020
Publisher :
Nature Portfolio, 2020.

Abstract

Recent evidence has questioned the dogma of strict maternal transmission of mitochondrial DNA (mtDNA) in humans. Wei et al. saw no evidence of paternal transmission of mtDNA in 11,035 human trios, and show that nuclear-mitochondrial segments (NUMTs) can give the impression of paternal mtDNA transmission, but are actually inherited through the nuclear genome.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
11
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1b33ee54b03a414c950db059cdfe623d
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-020-15336-3