Effects of enoxaparin on the healing of abdominal wall in rats: study on breaking strength and histopatology Efeitos da enoxaparina sobre a cicatrização da parede abdominal de ratos: estudo da força de ruptura e histopatológico

PURPOSE: To evaluate the influence of enoxaparin on the abdominal wall healing. METHODS: Sixty Wistar male rats were randomly distributed into two experimental groups. Group E: consisted of 30 rats, submitted to abdominal suture and treated with enoxaparin in a dose of 1 mg/kg of body weight, subcutaneously administered from immediate postoperative until the 7th day; Group C: consisted of 30 rats submitted to abdominal suture and treated with the equivalent dose per volume of NaCl 0.9%. The animals were submitted to median laparotomy and were operated again at the 3rd, 7th or 14th postoperative day for the resection of the anterior abdominal wall. The tissue's stretching resistance was tested and a histopathological evaluation was performed. Through Mann-Whitney's U test, a statistical analysis was conducted considering significant values for p OBJETIVO: Avaliar a influência da enoxaparina, sobre a cicatrização da parede abdominal. MÉTODOS: Foram utilizados 60 ratos Wistar, distribuídos aleatoriamente em grupo estudo (E) e controle (C). O grupo E recebeu 1 mg/kg de enoxaparina, via subcutânea, do pós-operatório imediato até o 7º dia pós-operatório (DPO); o grupo C doses-volume equivalentes de NaCl 0,9%. Os animais foram submetidos à laparotomia mediana e reoperados no 3º, 7º ou 14º DPO, para ressecção da parede abdominal anterior. A resistência tênsil foi testada e feita avaliação histopatológica. Análise estatística realizada com o teste U de Mann-Whitney, considerando significantes valores de p