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Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 and/or BACE2 Activators as the Optimal Therapeutic Strategy for Alzheimer’s Disease
- Source :
- International Journal of Molecular Sciences, Vol 25, Iss 18, p 9913 (2024)
- Publication Year :
- 2024
- Publisher :
- MDPI AG, 2024.
-
Abstract
- The present study analyzes two potential therapeutic approaches for Alzheimer’s disease (AD). One is the suppression of the neuronal integrated stress response (ISR). Another is the targeted degradation of intraneuronal amyloid-beta (iAβ) via the activation of BACE1 (Beta-site Aβ-protein-precursor Cleaving Enzyme) and/or BACE2. Both approaches are rational. Both are promising. Both have substantial intrinsic limitations. However, when combined in a carefully orchestrated manner into a composite therapy they display a prototypical synergy and constitute the apparently optimal, potentially most effective therapeutic strategy for AD.
- Subjects :
- conventional and unconventional Alzheimer’s disease
neuronal integrated stress response (ISR)
intraneuronal Aβ (iAβ)
AβPP-independent generation of iAβ
amyloid cascade hypothesis 2.0 (ACH2.0)
therapeutic strategies for conventional and unconventional Alzheimer’s disease
Biology (General)
QH301-705.5
Chemistry
QD1-999
Subjects
Details
- Language :
- English
- ISSN :
- 25189913, 14220067, and 16616596
- Volume :
- 25
- Issue :
- 18
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1b2774238f324c59a72f9fd0dc09e334
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ijms25189913