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Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19

Authors :
Ronja Mothes
Anna Pascual-Reguant
Ralf Koehler
Juliane Liebeskind
Alina Liebheit
Sandy Bauherr
Lars Philipsen
Carsten Dittmayer
Michael Laue
Regina von Manitius
Sefer Elezkurtaj
Pawel Durek
Frederik Heinrich
Gitta A. Heinz
Gabriela M. Guerra
Benedikt Obermayer
Jenny Meinhardt
Jana Ihlow
Josefine Radke
Frank L. Heppner
Philipp Enghard
Helena Stockmann
Tom Aschman
Julia Schneider
Victor M. Corman
Leif E. Sander
Mir-Farzin Mashreghi
Thomas Conrad
Andreas C. Hocke
Raluca A. Niesner
Helena Radbruch
Anja E. Hauser
Source :
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Publication Year :
2023
Publisher :
Nature Portfolio, 2023.

Abstract

Infection with SARS-CoV-2 has been linked with substantive inflammation, lung pathology and development of COVID-19. Here the authors spatially associate CCL18 and CCL21 in distinct tissue niches with lung pathology of severe COVID-19.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
14
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.1b2247b6d5234d329b89d09ddd2a8d84
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-023-36333-2