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Assessment of Left Atrial Fibrosis by Cardiac Magnetic Resonance Imaging in Ischemic Stroke Patients Without Atrial Fibrillation: A Systematic Review and Meta‐Analysis

Authors :
Jin Hean Koh
Lincoln Kai En Lim
Ying Kiat Tan
Claire Goh
Yao Hao Teo
Jamie Sin Ying Ho
Mayank Dalakoti
Mark Yan Yee Chan
Ching‐Hui Sia
Leonard Leong Litt Yeo
Benjamin Yong Qiang Tan
Source :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 17 (2024)
Publication Year :
2024
Publisher :
Wiley, 2024.

Abstract

Background Left atrial (LA) fibrosis is a marker of atrial cardiomyopathy and has been reported to be associated with both atrial fibrillation and ischemic stroke. Elucidating this relationship is clinically important as LA fibrosis could serve as a surrogate biomarker of LA cardiomyopathy. The objective of this study is to investigate the association of LA fibrosis and embolic stroke of undetermined source (ESUS) using cardiac magnetic resonance imaging. Methods and Results Following an International Prospective Register of Systematic Reviews‐registered protocol, 3 blinded reviewers performed a systematic review for studies that quantified the degree of LA fibrosis in patients with ESUS as compared with healthy patients from inception to February 2024. A meta‐analysis was conducted in the mean difference. From 7 studies (705 patients), there was a significantly higher degree of LA fibrosis in patients with ESUS compared with healthy controls (MD, 5.71% [95% CI, 3.55%–7.87%], P

Details

Language :
English
ISSN :
20479980
Volume :
13
Issue :
17
Database :
Directory of Open Access Journals
Journal :
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Publication Type :
Academic Journal
Accession number :
edsdoj.1ae83ebe6cb4d919cb21251ce2eff6d
Document Type :
article
Full Text :
https://doi.org/10.1161/JAHA.123.033059