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Comorbidity of functional bowel disorders and obesity in terms of microbiome

Authors :
E. S. Klimenko
N. L. Belkova
A. V. Pogodina
L. V. Rychkova
M. A. Darenskaya
Source :
Acta Biomedica Scientifica, Vol 7, Iss 5-2, Pp 56-66 (2022)
Publication Year :
2022
Publisher :
Scientific Сentre for Family Health and Human Reproduction Problems, 2022.

Abstract

Bacterial ecosystem of the gut plays a fundamental role in the normal functioning of the metabolic and immune systems. Functional bowel disease and obesity are highly prevalent in the population and place a heavy burden on healthcare system. Both comorbidity and multimorbidity are considered to be common for obesity and intestinal functional disorders. Changes in the microbiota can be both the cause and consequence of each disease: intestinal functional disorder changes the composition of the microbiota, resulting in obesity, and vice versa. Intestinal functional disorders and obesity are characterized by a similar type of dysbiosis.The aim of the review is to analyze the research findings available to date in order to establish the relationship between the gut microbiome, functional bowel disease and obesity. The researches have shown that patients with intestinal functional disorders have a different gut microbiome than healthy individuals. For intestinal functional disorders, the general patterns of the intestinal microbiota composition were described, and the characteristic taxonomic groups of bacteria were identified. On the other side, it must be noted that there is no clear correlation between intestinal functional disorders and obesity in terms of the microbiota. This can be explained by the high heterogeneity of intestinal functional disorders, as well as by the lack of a unified approach to creating a study design, by different sizes of population samples and also by different diagnostic criteria. The necessity to determine the criteria in the development of the design of future studies is discussed.

Details

Language :
Russian
ISSN :
25419420 and 25879596
Volume :
7
Issue :
5-2
Database :
Directory of Open Access Journals
Journal :
Acta Biomedica Scientifica
Publication Type :
Academic Journal
Accession number :
edsdoj.1abf9fc9d60341f88ee11981b2d648ff
Document Type :
article
Full Text :
https://doi.org/10.29413/ABS.2022-7.5-2.6