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Ten-day tegoprazan-based concomitant therapy as a first-line treatment for Helicobacter pylori eradication
- Source :
- The Korean Journal of Internal Medicine, Vol 38, Iss 4, Pp 493-503 (2023)
- Publication Year :
- 2023
- Publisher :
- The Korean Association of Internal Medicine, 2023.
-
Abstract
- Background/Aims Tegoprazan, a novel potassium-competitive acid blocker, has shown rapid action and gastric acid inhibition. In this study, we evaluated the efficacy of a tegoprazan-based, nonbismuth-containing quadruple (concomitant) therapy for the primary eradication of Helicobacter pylori. Methods We conducted a prospective, single-arm, single-center, primitive study to verify the efficacy of a 10-day tegoprazan-based (50-mg dose) concomitant therapy, including amoxicillin (1,000-mg dose), clarithromycin (CLA; 500-mg dose), and metronidazole (MET; 500-mg dose) twice daily as a first-line treatment for H. pylori eradication. Results We tested consecutive cultures for antibiotic susceptibility and minimum inhibitory concentrations. We enrolled 84 participants; 79 (94.0%) completed first-line therapy. The overall intention-to-treat and per-protocol eradication rates were 90.5% (95% confidence interval [CI], 82.1–95.8) and 96.2% (95% CI, 83.4–97.6), respectively. Of the 73 participants evaluated for antibiotic resistance, 19 (26.0%), 32 (42.5%), and 8 (11.0%) exhibited CLA, MET, and CLA and MET dual resistance, respectively. Of these, 39 participants (66.1%) exhibited successful eradication after the therapeutic regimen despite antibiotic resistance. Conclusions The 10-day tegoprazan-based concomitant therapy may be an effective first-line treatment for eradicating H. pylori.
- Subjects :
- antibiotic resistance
clarithromycin
metronidazole
tegoprazan
Medicine
Subjects
Details
- Language :
- English
- ISSN :
- 12263303 and 20056648
- Volume :
- 38
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- The Korean Journal of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.1aa3c67be4f70b1d92a1ffb77b94a
- Document Type :
- article
- Full Text :
- https://doi.org/10.3904/kjim.2022.345