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The Role of Co-Stimulatory Molecules in Chagas Disease

Authors :
Bruna F. Pinto
Nayara I. Medeiros
Tereza C. M. Fontes-Cal
Isabela M. Naziazeno
Rodrigo Correa-Oliveira
Walderez O. Dutra
Juliana A. S. Gomes
Source :
Cells, Vol 7, Iss 11, p 200 (2018)
Publication Year :
2018
Publisher :
MDPI AG, 2018.

Abstract

Chagas disease, caused by Trypanosoma cruzi, is a potentially life-threatening tropical disease endemic to Latin American countries that affects approximately 8 million people. In the chronic phase of the disease, individuals are classified as belonging to the indeterminate clinical form or to the cardiac and/or digestive forms when clinical symptoms are apparent. The relationship between monocytes and lymphocytes may be an important point to help clarify the complexity that surrounds the clinical symptoms of the chronic phase of Chagas disease. The co-stimulatory signals are essential to determining the magnitude of T cell response to the antigen. The signals are known to determine the regulation of subsequent adaptive immune response. However, little is known about the expression and function of these molecules in Chagas disease. Therefore, this review aims to discuss the possible role of main pathways of co-stimulatory molecule-receptor interactions in this pathology that could be crucial to understand the disease dynamics.

Details

Language :
English
ISSN :
20734409
Volume :
7
Issue :
11
Database :
Directory of Open Access Journals
Journal :
Cells
Publication Type :
Academic Journal
Accession number :
edsdoj.1a869c57e5994190afab0a800d10a4ec
Document Type :
article
Full Text :
https://doi.org/10.3390/cells7110200